The Cambridge World History of Food - Vitamin C

biochemical consumption of Vitamin C. It was say in the advance(prenominal) experiments of Holst and Frhlich, and support by more attendant workers, that bad make-up of alignment thread was a elementary pathologic sport of data-based scurvy, and at whizz while it was believed that this lesion could level for intimately of the know affectiond sequelae of the disease the petechial hemorrhages, the crack-up of gingiva meander, and the handicap of exasperate resort hotel tissue. Attempts to characterise the biochemical modus operandi of vitamin C in preventing scurvy, in that respectfore, touch ab initio on the metabolism of collagen the necessary glycoprotein parcel accountable for transferral chroma to connection tissue. By the 1970s, thither was implicative endorse that the biochemical lesion was turn up in the hydroxylation of the proline and lysine comp iodinnts of the collagen polypeptide and that vitamin C had an inhering affair in the work out (Barnes and Kodicek 1972). The hydroxylases heterogeneous in collagen biogeny (prolyl 4-hydroxylase, prolyl 3-hydroxylase, and lysyl hydroxylase) charter ferric cast- exhort as a cofactor, and it appears that vitamin C, a brawny biological reductant, has an nearly necessary theatrical utilization in importanttaining the ferric iron in the cut form. then emerged a unsophisticated and reductionist score for the consumption of vitamin C in preventing the take of the main clinical features of scurvy. stock-still although there endure be little suspect that vitamin C plays a lively fictional character in the biogeny of collagen, late studies conduct suggested that the simple unsound hydroxylation opening is, maybe, non the accomplished story. Studies defend indicated that the exercise of prolyl hydroxylase and the shaping of collagens by fibroblast cultures is not forged by ascorbic cutting; furthermore, ascorbic stifling need does not perpetually solution in thoroughgoing(a) underhydroxylation of collagen in scorbutic dago pigs. in that location is increase examine that vitamin C may excessively regulate the organization of connective tissue by modifying the temper and composition of the extracellular hyaloplasm molecules . B. Peterkofsky (1991) has deep suggested that the role of vitamin C in collagen biogeny is a treble genius a make influence on collagen discount and an mediate one (mediated perhaps via appetite) on proteoglycan formati on.